Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019

被引：33

作者：

Zhai, Xiaofeng ^{[1
]}

Zhao, Wen ^{[1
]}

Li, Kemang ^{[1
]}

Zhang, Cheng ^{[1
]}

Wang, Congcong ^{[1
]}

Su, Shuo ^{[1
]}

Zhou, Jiyong ^{[2
]}

Lei, Jing ^{[1
]}

Xing, Gang ^{[2
]}

Sun, Haifeng ^{[1
]}

Shi, Zhiyu ^{[1
]}

Gu, Jinyan ^{[1
]}

机构：

[1] Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Engn Lab Anim Immun Jiangsu Prov, Nanjing 210000, Jiangsu, Peoples R China

[2] Zhejiang Univ, Key Lab Anim Virol, Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China

来源：

VIROLOGICA SINICA | 2019年 / 34卷 / 06期

关键词：

Pseudorabies virus (PRV); Glycoproteins; Founder effect; Epidemic; Eastern China; BARTHA-K61-VACCINATED SWINE POPULATION; PHYLOGENETIC ANALYSIS; BINDING DOMAIN; VARIANT; PATHOGENESIS; ATTACHMENT; SEQUENCE; EPIDEMIOLOGY; GENETICS; SITES;

D O I：

10.1007/s12250-019-00140-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Since late 2011, outbreaks of pseudorabies virus (PRV) have occurred in southern China causing major economic losses to the pig industry. We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics. Here, we analyzed samples from intensive pig farms in eastern China between 2017 and 2019, and sequenced the main glycoproteins (gB, gC, gD, and gE) to study the evolution characteristics of PRV. Based on the gC gene, we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic. In addition, we detected inter- and intra-clade recombination; in particular, inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2, which were recombinant with clade 1 strains. We also found specific amino-acid changes and positively selected sites, possibly associated with functional changes. This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV.

引用

页码：601 / 609

页数：9

共 42 条

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