The TNF-α-238G > A single-nucleotide polymorphism protects against memory decline in older adults with type 2 diabetes

被引：7
作者：
Chui, Michael H.
Papanikolaou, Yanni
Fontaine-Bisson, Benedicte
Turcotte, Josee
Wolever, Thomas M. S.
El-Sohemy, Ahmed
Chiasson, Jean-Louis
Rabasa-Lhoret, Rerm
Maheux, Pierre
Ryan, Edmond
Greenwood, Carol E.
机构：
[1] Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada
[2] Laurentian Univ, Dept Psychol, Sudbury, ON P3E 2C6, Canada
[3] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON M5B 1W8, Canada
[4] CHU Montreal, Montreal, PQ, Canada
[5] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada
[6] Univ Sherbrooke, Div Endocrinol & Metab, Sherbrooke, PQ J1K 2R1, Canada
[7] Univ Alberta, Edmonton, AB, Canada
[8] Baycrest, Kunin Lunenfeld Appl Res Unit, Toronto, ON, Canada
[9] Baycrest, Dept Food & Nutr Serv, Toronto, ON, Canada
来源：
BEHAVIORAL NEUROSCIENCE | 2007年 / 121卷 / 03期
关键词：
type; 2; diabetes; inflammation; TNF-alpha; memory; cognition;
D O I：
10.1037/0735-7044.121.3.619
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Inflammatory markers predict memory dysfunction in elderly patients, but their contribution to memory deficits in adults with Type 2 diabetes mellitus (T2DM) is less well understood. The present study determined whether specific single-nucleotide polymorphisms in the promoter region of tumor necrosis factor alpha (TNF-alpha) predict verbal memory in older patients with T2DM. Immediate and delayed verbal memory were assessed using word list and paragraph recall tests in a cohort of subjects with T2DM during 2 sessions, separated by 48 weeks. The presence of the TNF-alpha-238A allele, which has been shown to decrease gene expression, consistently predicted better baseline performance and protected against memory decline over a period of 48 weeks. Therefore, inflammatory mediators may be important modulator,,; of memory function in individuals with T2DM.
引用
收藏
页码：619 / 624
页数：6
相关论文
共 28 条
[1]   The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function [J].
Awad, N ;
Gagnon, M ;
Messier, C .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2004, 26 (08) :1044-1080
[2]   AN INVENTORY FOR MEASURING DEPRESSION [J].
BECK, AT ;
ERBAUGH, J ;
WARD, CH ;
MOCK, J ;
MENDELSOHN, M .
ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) :561-&
[3]   REDUCED LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF TRANSGENIC MICE WITH CEREBRAL OVEREXPRESSION OF INTERLEUKIN-6 [J].
BELLINGER, FP ;
MADAMBA, SG ;
CAMPBELL, IL ;
SIGGINS, GR .
NEUROSCIENCE LETTERS, 1995, 198 (02) :95-98
[4]  
CONNELLY PW, 1992, CAN MED ASSOC J, V146, P1977
[5]   The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels [J].
FernandezReal, JM ;
Gutierrez, C ;
Ricart, W ;
Casamitjana, R ;
FernandezCastaner, M ;
Vendrell, J ;
Richart, C ;
Soler, J .
DIABETES, 1997, 46 (09) :1468-1472
[6]  
FINK PC, 1989, J CLIN CHEM CLIN BIO, V27, P261
[7]   Hyperinsulinemia provokes synchronous increases in central inflammation and β-amyloid in normal adults [J].
Fishel, MA ;
Watson, S ;
Montine, TJ ;
Wang, Q ;
Green, PS ;
Kulstad, JJ ;
Cook, DG ;
Peskind, ER ;
Baker, LD ;
Goldgaber, D ;
Nie, W ;
Asthana, S ;
Plymate, SR ;
Schwartz, MW ;
Craft, S .
ARCHIVES OF NEUROLOGY, 2005, 62 (10) :1539-1544
[8]   Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats [J].
García-Bueno, B ;
Madrigal, JLM ;
Lizasoain, I ;
Moro, MA ;
Lorenzo, P ;
Leza, JC .
BIOLOGICAL PSYCHIATRY, 2005, 57 (08) :885-894
[9]   Carbohydrate-induced memory impairment in adults with type 2 diabetes [J].
Greenwood, CE ;
Kaplan, RJ ;
Hebblethwaite, S ;
Jenkins, DJA .
DIABETES CARE, 2003, 26 (07) :1961-1966
[10]   The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease [J].
Hull, M ;
Strauss, S ;
Berger, M ;
Volk, B ;
Bauer, J .
BEHAVIOURAL BRAIN RESEARCH, 1996, 78 (01) :37-41
123