How to Conduct and Interpret Systematic Reviews and Meta-Analyses

被引：36

作者：

Singh, Siddharth ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Div Gastroenterol, 9452 Med Ctr Dr,1W 501, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Div Biomed Informat, La Jolla, CA 92093 USA

来源：

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2017年 / 8卷

关键词：

D O I：

10.1038/ctg.2017.20

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Systematic reviews with or without meta-analyses serve a key purpose in critically and objectively synthesizing all available evidence regarding a focused clinical question and can inform clinical practice and clinical guidelines. Performing a rigorous systematic review is multi-step process, which includes (a) identifying a well-defined focused clinically relevant question, (b) developing a detailed review protocol with strict inclusion and exclusion criteria, (c) systematic literature search of multiple databases and unpublished data, in consultation with a medical librarian, (d) meticulous study identification and (e) systematic data abstraction, by at least two sets of investigators independently, (f) risk of bias assessment, and (g) thoughtful quantitative synthesis through meta-analysis where relevant. Besides informing guidelines, credible systematic reviews and quality of evidence assessment can help identify key knowledge gaps for future studies.

引用

页数：5

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