Synthesis and Analgesic Activity of [b]-Annelated 4-Quinolones

被引：5

作者：

Boteva, A. A. ^{[1
]}

Fefilova, I., V ^{[1
]}

Triandafilova, G. A. ^{[1
]}

Maslova, V. V. ^{[1
]}

Solodnikov, S. Yu ^{[1
]}

Krasnykh, O. P. ^{[1
]}

机构：

[1] Perm Natl Res Polytech Univ, Sci Educ Ctr Appl Chem & Biol Res, 29 Komsomolskii Prospekt, Perm 614990, Perm District, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 07期

关键词：

b]-annelated 4-quinolones; analgesic activity; antinociceptive action;

D O I：

10.1007/s11094-019-02048-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Considering the side effects of existing drugs used for pain relief, the search for new analgesics with high efficacy and safety remains relevant. Aseries of imidazopyrrolo[3,4-b]quinoline-5,11-diones and pyrimidopyrrolo[3,4-b]quinoline-6,12-diones II were synthesized, whose analgesic activity at a dose of 0.05 mmol/kg was studied in the hotplate test in rats after i.p. administration. One compound was found with analgesic activity comparable to that of reference compound diclofenac sodium. Compounds II were less toxic than diclofenac sodium.

引用

页码：616 / 619

页数：4

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