Preparation of gelatin/PVA nanofibers and their potential application in controlled release of drugs

被引：235

作者：

Yang, Dongzhi ^{[1
]}

Li, Yanning ^{[1
]}

Nie, Jun ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Coll Mat Sci & Engn, Beijing 100029, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2007年 / 69卷 / 03期

关键词：

electrospinning; gelatin; PVA; raspberry ketone;

D O I：

10.1016/j.carbpol.2007.01.008

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Gelatin/PVA bicomponent nanofibers were prepared via electrospinning, and its control release of Raspberry ketone(RK) was investigated. Significant diameter increase, tensile strength and elongation at break improvement were observed as the ratio of PVA increased. The burst release of drug was observed in the first hour, and reached a plateau after two hours. The RK release rate could be tailored by the GEL/PVA ratio, the content of loaded RK, and the crosslinking time of glutaraldehyde vapor. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：538 / 543

页数：6

共 30 条

[1] Sustained release of proteins from electrospun biodegradable fibers [J].