Molecular mechanisms regulating hormone-sensitive lipase and lipolysis

被引：338

作者：

Holm, C ^{[1
]}

Osterlund, T ^{[1
]}

Laurell, H ^{[1
]}

Contreras, JA ^{[1
]}

机构：

[1] Univ Lund, Dept Cell & Mol Biol, Sect Mol Signalling, Lund, Sweden

来源：

ANNUAL REVIEW OF NUTRITION | 2000年 / 20卷

关键词：

fatty acid mobilization; adipose tissue; cholesteryl ester hydrolase; perilipin; protein kinase A;

D O I：

10.1146/annurev.nutr.20.1.365

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a pivotal role in lipid metabolism, overall energy homeostasis, and, presumably, cellular events involving fatty acid signaling. Detailed knowledge about its structure and regulation may provide information regarding the pathogenesis of such human diseases as obesity and diabetes and may generate concepts for new treatments of these diseases. The current review summarizes the recent advances with regard to hormone-sensitive lipase structure and molecular mechanisms involved in regulating its activity and lipolysis in general. A summary of the current knowledge regarding regulation of expression, potential involvement in lipid disorders, and role in tissues other than adipose tissue is also provided.

引用

页码：365 / +

页数：30

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