The emerging role of β-secretases in cancer

被引：26
作者：
Farris, Francesco [1 ]
Matafora, Vittoria [1 ]
Bachi, Angela [1 ]
机构：
[1] IFOM FIRC Inst Mol Oncol, Milan, Italy
来源：
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2021年 / 40卷 / 01期
关键词：
BACE1; BACE2; Amyloid aggregates; Tumor microenvironment; Cancer; AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; TUMOR MICROENVIRONMENT; DIABETES-MELLITUS; BACE2; INHIBITION; EXPRESSION; CLEAVAGE; PMEL; SITE;
D O I：
10.1186/s13046-021-01953-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACE1 and BACE2 belong to a class of proteases called beta-secretases involved in ectodomain shedding of different transmembrane substrates. These enzymes have been extensively studied in Alzheimer's disease as they are responsible for the processing of APP in neurotoxic A beta peptides. These proteases, especially BACE2, are overexpressed in tumors and correlate with poor prognosis. Recently, different research groups tried to address the role of BACE1 and 2 in cancer development and progression. In this review, we summarize the latest findings on beta-secretases in cancer, highlighting the mechanisms that build the rationale to propose inhibitors of these proteins as a new line of treatment for different tumor types.
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页数：10
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