Synthesis and Antitumor Activity Evaluation of Novel Tetrahydro[4,5]benzothieno[2,3-d]pyrimidinone Derivatives

被引：2

作者：

Chen, Yu ^{[1
]}

Bai, Shun ^{[1
]}

He, Hongwu ^{[2
]}

Yang, Guangzhong ^{[3
]}

机构：

[1] South Cent Univ Nationalities, Coll Chem & Mat Sci, Wuhan 430074, Peoples R China

[2] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China

[3] South Cent Univ Nationalities, Coll Pharm, Wuhan 430074, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 34卷 / 11期

关键词：

thieno[2,3-d]pyrimidinone derivatives; antitumor activity; Gewald reaction; KINASE INHIBITORS;

D O I：

10.6023/cjoc201405018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six 3-alkyl-5,6,7,8-tetrahydro[4,5]benzothieno[2,3-d]pyrimidin-4-one derivatives and seventeen 3-benzylidene-aminotetrahydrobenzo[4,5]thieno[2,3-4pyrimidin-4-one derivatives have been designed and synthesized via Gewald reaction under mild condition. The structures of synthesized compounds were characterized by H-1 NMR, C-13 NMR, IR and MS. Their antitumor activities were evaluated against human nasopharyngeal carcinoma (KB) and human nasopharyngeal carcinoma (CNE2) cell lines in vitro. These results revealed that four tested compounds showed moderate antitumor activities.

引用

页码：2362 / 2369

页数：8

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