Novelty and fear conditioning induced gene expression in high and low states of anxiety

被引:7
作者
Donley, Melanie P. [1 ]
Rosen, Jeffrey B. [1 ]
机构
[1] Univ Delaware, Dept Psychol & Brain Sci, Newark, DE 19716 USA
关键词
ENVIRONMENTAL ENRICHMENT; HUMAN AMYGDALA; PREFRONTAL CORTEX; NEUTRAL FACES; C-FOS; INDIVIDUAL-DIFFERENCES; SYNAPTIC PLASTICITY; NEURONAL ENSEMBLES; HUMAN HIPPOCAMPUS; RAT-BRAIN;
D O I
10.1101/lm.044289.116
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Emotional states influence how stimuli are interpreted. High anxiety states in humans lead to more negative, threatening interpretations of novel information, typically accompanied by activation of the amygdala. We developed a handling protocol that induces long-lasting high and low anxiety-like states in rats to explore the role of state anxiety on brain activation during exposure to a novel environment and fear conditioning. In situ hybridization of the inducible transcription factor Egr-1 found increased gene expression in the lateral nucleus of the amygdala (LA) following exposure to a novel environment and contextual fear conditioning in high anxiety-like rats. In contrast, low state anxiety-like rats did not generate Egr-1 increases in LA when placed in a novel chamber. Egr-1 expression was also examined in the dorsal hippocampus and prefrontal cortex. In CA1 of the hippocampus and medial prefrontal cortex (mPFC), Egr-1 expression increased in response to novel context exposure and fear conditioning, independent of state anxiety level. Furthermore, in mPFC, Egr-1 in low anxiety-like rats was increased more with fear conditioning than novel exposure. The current series of experiments show that brain areas involved in fear and anxiety-like states do not respond uniformly to novelty during high and low states of anxiety.
引用
收藏
页码:449 / 461
页数:13
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