Strategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug Candidates

被引：45

作者：

Palucki, Michael ^{[1
]}

Higgins, John D. ^{[1
]}

Kwong, Elizabeth ^{[1
]}

Templeton, Allen C. ^{[1
]}

机构：

[1] Merck & Co Inc, Basic Pharmaceut Sci, Merck Res Labs, West Point, PA 19486 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 16期

关键词：

DISSOLUTION; SOLUBILITY; SELECTION; BIOAVAILABILITY; ABSORPTION; DELIVERY;

D O I：

10.1021/jm1002638

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：5897 / 5905

页数：9

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