Phospholipase A2 hydrolysis of mixed phospholipid vesicles formed on polyelectrolyte hollow capsules

被引：43
|
作者：
Ge, LQ
Möhwald, H
Li, JB [1 ]
机构：
[1] Chinese Acad Sci, Int Joint Lab, Key Lab Colloid & Interface Sci, Ctr Mol Sci,Inst Chem, Beijing 100080, Peoples R China
[2] Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2003年 / 9卷 / 11期
关键词：
D O I：
10.1002/chem.200304315
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mixtures of the phospholipids L-alpha-dimyristoylphosphatidic acid (DMPA) and L-alpha-dipaimitoylphosphatidylcholine (DPPC) have been successfully adsorbed onto the charged surface of multilayer polyelectrolyte capsules to form a. novel vesicle. Leaving such vesicles in phospholipase A(2) solution, we observed the hydrolysis reaction on the surface of the lipid/polymer vesicles and a permeability change before and after the reaction by confocal-laser scanning microscopy (CLSM). A capsule with adjustable permeability was constructed. This method may provide new features for drug-release vesicles.
引用
收藏
页码：2589 / 2594
页数：6
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