Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell-line mouse models

被引：109

作者：

Hiroshima, Yukihiko ^{[1
,2
,3
]}

Zhang, Yong ^{[1
]}

Murakami, Takashi ^{[3
]}

Maawy, Ali ^{[2
]}

Miwa, Shinji ^{[1
,2
]}

Yamamoto, Mako ^{[1
,2
]}

Yano, Shuya ^{[1
,2
]}

Sato, Sho ^{[3
]}

Momiyama, Masashi ^{[3
]}

Mori, Ryutaro ^{[3
]}

Matsuyama, Ryusei ^{[3
]}

Chishima, Takashi ^{[3
]}

Tanaka, Kuniya ^{[3
]}

Ichikawa, Yasushi ^{[3
]}

Bouvet, Michael ^{[2
]}

Endo, Itaru ^{[3
]}

Zhao, Ming ^{[1
]}

Hoffman, Robert M. ^{[1
,2
]}

机构：

[1] AntiCancer Inc, San Diego, CA 92111 USA

[2] Univ Calif San Diego, Dept Surg, San Diego, CA 92103 USA

[3] Yokohama City Univ, Grad Sch Med, Yokohama, Kanagawa 232, Japan

来源：

ONCOTARGET | 2014年 / 5卷 / 23期

关键词：

Pancreatic cancer; Salmonella typhimurium A1-R; patient-derived orthotopic xenograft (PDOX); orthotopic; nude mice; GFP; VEGF; anti-angiogenic therapy; bevacizumab; gemcitabine; ENDOTHELIAL GROWTH-FACTOR; NUDE-MICE; HIGH EXPRESSION; POOR-PROGNOSIS; COLON-CANCER; CHEMOTHERAPY; METASTASIS; TRANSPLANTATION; TISSUE;

D O I：

10.18632/oncotarget.2641

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of the present study was to examine the efficacy of tumor-targeting Salmonella typhimurium A1-R treatment following anti-vascular endothelial growth factor (VEGF) therapy on VEGF-positive human pancreatic cancer. A pancreatic cancer patient-derived orthotopic xenograft (PDOX) that was VEGF-positive and an orthotopic VEGF-positive human pancreatic cancer cell line (MiaPaCa-2-GFP) as well as a VEGF-negative cell line (Panc-1) were tested. Nude mice with these tumors were treated with gemcitabine (GEM), bevacizumab (BEV), and S. typhimurium A1-R. BEV/GEM followed by S. typhimurium A1-R significantly reduced tumor weight compared to BEV/GEM treatment alone in the PDOX and MiaPaCa-2 models. Neither treatment was as effective in the VEGF-negative model as in the VEGF-positive models. These results demonstrate that S. typhimurium A1-R following anti-angiogenic therapy is effective on pancreatic cancer including the PDOX model, suggesting its clinical potential.

引用

页码：12346 / 12357

页数：12

共 39 条

[1] A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer [J].