Pd-catalyzed oxidative C-H alkenylation for synthesizing arylvinyltriazole nucleosides

被引：12

作者：

Tang, Jingjie ^{[1
]}

Cong, Mei ^{[1
]}

Xia, Yi ^{[1
,2
,3
]}

Quelever, Gilles ^{[1
]}

Fan, Yuting ^{[1
,4
]}

Qu, Fanqi ^{[4
]}

Peng, Ling ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, CINaM, UMR 7325, F-13288 Marseille, France

[2] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada

[3] Univ British Columbia, Dept Urol Sci, Vancouver, BC V6H 3Z6, Canada

[4] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 01期

关键词：

DEHYDROGENATIVE HECK REACTIONS; RESISTANT PANCREATIC-CANCER; POTENT ANTICANCER ACTIVITY; CROSS-COUPLING REACTIONS; AROMATIC-SUBSTITUTION; PALLADIUM; ARYLATION; OLEFINS; ACYCLONUCLEOSIDES; ACTIVATION;

D O I：

10.1039/c4ob01836b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various arylvinyltriazole nucleoside analogues were synthesized using Pd-catalyzed oxidative Heck reaction. This method affords the corresponding and otherwise difficult to achieve arylvinyltriazole nucleosides with good yields and large functional group compatibility. These results further advocate the potential and practicality of this oxidative C-H alkenylation method for generating structurally challenging chemical entities in organic synthesis.

引用

页码：110 / 114

页数：5

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