Wireless Optogenetic Modulation of Cortical Neurons Enabled by Radioluminescent Nanoparticles

被引：40

作者：

Chen, Zhaowei ^{[1
,2
]}

Tsytsarev, Vassiliy ^{[9
]}

Finfrock, Y. Zou ^{[3
,4
]}

Antipova, Olga A. ^{[3
]}

Cai, Zhonghou ^{[3
]}

Arakawa, Hiroyuki ^{[5
]}

Lischka, Fritz W. ^{[6
]}

Hooks, Bryan M. ^{[7
]}

Wilton, Rosemarie ^{[8
]}

Wang, Dongyi ^{[9
]}

Liu, Yi ^{[9
]}

Gaitan, Brandon ^{[9
]}

Tao, Yang ^{[9
]}

Chen, Yu ^{[9
]}

Erzurumlu, Reha S. ^{[5
]}

Yang, Huanghao ^{[2
]}

Rozhkova, Elena A. ^{[1
]}

机构：

[1] Argonne Natl Lab, Ctr Nanoscale Mat, 9700 S Cass Ave, Argonne, IL 60439 USA

[2] Fuzhou Univ, Coll Chem, Inst Food Safety & Environm Monitoring, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350108, Peoples R China

[3] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA

[4] Canadian Light Source Inc, Sci Div, Saskatoon, SK S7N 2V3, Canada

[5] Univ Maryland, Dept Anat & Neurobiol, Sch Med, Baltimore, MD 21201 USA

[6] Uniformed Serv Univ Hlth Sci, Biomed Instrumentat Ctr, Bethesda, MD 20814 USA

[7] Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA 15213 USA

[8] Argonne Natl Lab, Biosci, 9700 S Cass Ave, Argonne, IL 60439 USA

[9] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA

来源：

ACS NANO | 2021年 / 15卷 / 03期

基金：

美国国家科学基金会;

关键词：

optogenetics; X-ray excited optical luminescence (XEOL) nanoparticles; channelrhodopsin; wireless neuromodulation; in vivo;

D O I：

10.1021/acsnano.0c10436

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

While offering high-precision control of neural circuits, optogenetics is hampered by the necessity to implant fiber-optic waveguides in order to deliver photons to genetically engineered light-gated neurons in the brain. Unlike laser light, X-rays freely pass biological barriers. Here we show that radioluminescent Gd-2(WO4)(3):Eu nanoparticles, which absorb external X-rays energy and then downconvert it into optical photons with wavelengths of similar to 610 nm, can be used for the transcranial stimulation of cortical neurons expressing red-shifted, similar to 590-630 nm, channelrhodopsin ReaChR, thereby promoting optogenetic neural control to the practical implementation of minimally invasive wireless deep brain stimulation.

引用

页码：5201 / 5208

页数：8

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