Comparison of video analysis and simulations of a drum coating process

被引：14

作者：

Boehling, P. ^{[1
]}

Toschkoff, G. ^{[1
]}

Dreu, R. ^{[2
]}

Just, S. ^{[2
]}

Kleinebudde, P. ^{[2
]}

Funke, A. ^{[4
]}

Rehbaum, H. ^{[5
]}

Khinast, J. G. ^{[1
,3
]}

机构：

[1] Res Ctr Pharmaceut Engn GmbH, Graz, Austria

[2] Heinrich Heine Univ, Inst Pharmaceut & Biopharmaceut, Dusseldorf, Germany

[3] Graz Univ Technol, Inst Proc & Particle Engn, Graz, Austria

[4] Bayer Pharma AG, Chem & Pharmaceut Dev, Berlin, Germany

[5] LB Bohle Maschinen Verfahren GmbH, Ennigerloh, Germany

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2017年 / 104卷

关键词：

Tablet coating; Simulation; DEM; Experiments; DISCRETE ELEMENT METHOD; PAN COATERS; VARIABILITY; PREDICTION; VELOCITIES; UNIFORMITY; TABLETS; SHAPE;

D O I：

10.1016/j.ejps.2017.03.031

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tablet coating is a common unit operation in the pharmaceutical industry. To improve currently established processes, it is important to understand the influence of the process parameters on the coating quality. One of the critical parameters is the tablet velocity. In this work, numerical results are compared to results obtained experimentally. Tablet movement in the drums was simulated using the Discrete Element Method (DEM). The simulation parameters were adapted to fit the simulation to the experimental data. A comparison of the experimental and simulation results showed that the simulation correctly represents the real tablet velocity. A change in the velocity over time and its dependence on the rotation rates and the baffle position in the simulation were similar to the experimental results. In summary, simulations can improve the understanding of tablet coating processes and will thus provide insights into the underlying process mechanics, which cannot be obtained via ordinary experiments.

引用

页码：72 / 81

页数：10

共 28 条

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