Neoadjuvant Strategies for the Treatment of Locally Advanced Esophageal Cancer

被引：35

作者：

Hyngstrom, John R. ^{[1
]}

Posner, Mitchell C. ^{[1
]}

机构：

[1] Univ Chicago, Med Ctr, Sect Gen Surg, Dept Surg, Chicago, IL 60637 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 101卷 / 04期

关键词：

esophageal neoplasm; neoadjuvant therapy; combined modality therapy; definitive chemoradiotherapy; RANDOMIZED CLINICAL-TRIAL; SQUAMOUS-CELL CARCINOMA; PHASE-III TRIAL; PREOPERATIVE RADIOTHERAPY; SURGERY; CHEMOTHERAPY; CHEMORADIOTHERAPY; CHEMORADIATION; SURVIVAL; METAANALYSIS;

D O I：

10.1002/jso.21479

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with locally advanced esophageal carcinoma have consistently poor Survival following surgery with associated high systemic and local-regional failure rates. Neoadjuvant therapeutic strategies have been employed in an attempt to improve outcome with variable success. Randomized trials of either neoadjuvant chemotherapy or chemoradiotherapy have shown conflicting results regarding survival and local-regional control. Future efforts should focus on identifying novel agents and targets to improve therapeutic efficacy. J. Surg. Oncol. 2010; 101:299-304. (C) 2010 Wiley-Liss, Inc.

引用

页码：299 / 304

页数：6

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