Design and characterization of a large-area, lens-coupled CCD detector for macromolecular crystallography

被引：0

作者：

Westbrook, EM ^{[1
]}

Morse, J ^{[1
]}

Fisher, RE ^{[1
]}

McGuigan, W ^{[1
]}

Onishi, S ^{[1
]}

Vu, P ^{[1
]}

Naday, I ^{[1
]}

Bauer, C ^{[1
]}

Phillips, J ^{[1
]}

Thorson, TA ^{[1
]}

Durst, RD ^{[1
]}

机构：

[1] Mol Biol Consortium, Burr Ridge, IL 60527 USA

来源：

X-RAY AND GAMMA-RAY DETECTORS AND APPLICATIONS IV | 2002年 / 4784卷

关键词：

protein crystallography; x-ray detector; x-ray diffraction; CCD; lens optics;

D O I：

暂无

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

We have prototyped and characterized a very large format X-ray detector for macromolecular crystallography. The X-ray field strength is converted to visible light in a phosphor film. Light from the phosphor is focused onto a CCD imager by a lens specially designed for this detector; that has a very high numerical aperture. The CCD is very large (61 mm, 4,096x4,096 pixels), and employs a very low-noise on-chip preamplifier. Lens coupling between phosphor film and CCD avoids many of the optical imperfections of fiber optic coupling, but it remains a challenge to make a lens system with optical transfer efficiency matching or exceeding that of fiber optical systems. We have met this challenge by enhancing system gain in our detector through implementation of modern lens technologies and imaginative CCD design. At this point the system gain equals that of conventional CCD-based X-ray crystallography detectors, which couple the CCD to the phosphor through a fiber optic taper. Although many of our technical developments could also be used in fiber optic detectors, the overriding virtues of the lens-coupled detector are simplicity, optical perfection; and cost.

引用

页码：375 / 385

页数：11

共 21 条

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[2]

*FAIRCH IM SYST, 2000, CCD486 FAIRCH IM SYS

[3]

Fischer R. E., 2000, OPTICAL SYSTEM DESIG

[4]

Helliwell J. R., 1992, MACROMOLECULAR CRYST