Illuminating cytochrome P450 binding: Ru(II)-caged inhibitors of CYP17A1

被引：60

作者：

Li, Ao ^{[1
]}

Yadav, Rahul ^{[2
]}

White, Jessica K. ^{[3
]}

Herroon, Mackenzie K. ^{[4
]}

Callahan, Brian P. ^{[5
]}

Podgorski, Izabela ^{[4
,6
]}

Turro, Claudia ^{[3
]}

Scott, Emily E. ^{[2
]}

Kodanko, Jeremy J. ^{[1
,6
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA

[3] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA

[4] Wayne State Univ, Sch Med, Dept Pharmacol, Detroit, MI 48201 USA

[5] Binghamton Univ, Dept Chem, Binghamton, NY 13902 USA

[6] Barbara Ann Karmanos Canc Inst, Detroit, MI 48201 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 26期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

PROSTATE-CANCER; VISIBLE-LIGHT; RUTHENIUM(II) COMPLEX; P450; INHIBITORS; CELL-LINES; ABIRATERONE; LIGANDS; 17A1;

D O I：

10.1039/c7cc01459g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New Ru(II)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode.

引用

页码：3673 / 3676

页数：4

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