Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat

被引:20
|
作者
Kim, Ran [1 ]
Hur, Daeun [1 ]
Kim, Hyoung Kyu [2 ]
Han, Jin [2 ]
Mishchenko, Natalia P. [3 ]
Fedoreyev, Sergey A. [3 ]
Stonik, Valentin A. [3 ]
Chang, Woochul [1 ]
机构
[1] Pusan Natl Univ, Coll Educ, Dept Biol Educ, Busan 46241, South Korea
[2] Inje Univ, CMDC, Coll Med, Dept Physiol,Natl Res Lab Mitochondrial Signaling, Busan 614735, South Korea
[3] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia
基金
新加坡国家研究基金会;
关键词
echinochrome A; brain ischemic stroke; cell survival; STROKE; PROLIFERATION; PROTEIN;
D O I
10.3390/md17090501
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired attention as an alternative clinical trial source for the treatment of ischemic stroke. The current study demonstrates considerable potential of Ech A as a medication for cerebral ischemic injury. To confirm the effects of Ech A on the recovery of the injured region and behavioral decline, Ech A was administered through the external carotid artery in a rat middle cerebral artery occlusion model after reperfusion. The expression level of cell viability-related factors was also examined to confirm the mechanism of brain physiological restoration. Based on the results obtained, we propose that Ech A ameliorates the physiological deterioration by its antioxidant effect which plays a protective role against cell death, subsequent to post cerebral ischemic stroke.
引用
收藏
页数:8
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