Direct N-alkylation of sulfur-containing amines

被引：4

作者：

Li, Chen ^{[1
]}

Ge, Min-Tong ^{[1
]}

Bai, Liang ^{[1
]}

Xia, Ai-Bao ^{[1
]}

Xu, Dan-Qian ^{[1
]}

Xu, Zhen-Yuan ^{[1
]}

机构：

[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Catalyt Hydrogenat Res Ctr, Hangzhou 310014, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 20期

基金：

浙江省自然科学基金;

关键词：

CATALYZED REDUCTIVE AMINATION; GROUP-8; TRANSITION-METALS; ONE-POT SYNTHESIS; BORROWING HYDROGEN; RUTHENIUM COMPLEX; CARBONYL HALIDES; VERSATILE CATALYST; ALCOHOLS; EFFICIENT; ARYL;

D O I：

10.1039/d1ob00368b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy. The present methodology features base-free conditions and broad substrate scope, with water being the only by-product. Moreover, this protocol has been applied to the synthesis of the pharmaceutical drug Quetiapine.

引用

页码：4478 / 4482

页数：5

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