Cardiovascular events and the role of accelerated atherosclerosis in systemic vasculitis

被引:43
作者
Clifford, Alison H. [1 ]
Tervaert, Jan Willem Cohen [1 ]
机构
[1] Univ Alberta, Dept Med, Div Rheumatol, Edmonton, AB T6G 2G3, Canada
关键词
Vasculitis; Atherosclerosis; Takayasu arteritis; Giant cell arteritis; ANCA; Cardiovascular disease; GIANT-CELL ARTERITIS; ANCA-ASSOCIATED VASCULITIS; NEUTROPHIL EXTRACELLULAR TRAPS; SUBCLINICAL ATHEROSCLEROSIS; ENDOTHELIAL DYSFUNCTION; RISK-FACTORS; TAKAYASUS-ARTERITIS; CARDIAC INVOLVEMENT; METABOLIC SYNDROME; GUT MICROBIOME;
D O I
10.1016/j.atherosclerosis.2021.03.032
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The spectrum of inflammatory blood vessel diseases includes both atherosclerosis and the primary systemic vasculitides. Although the inciting triggers differ, significant overlap exists in the mechanisms that contribute to sustained inflammation and vascular damage in both entities. With improvement in therapeutics to control acute vasculitis leading to longer survival, cardiovascular morbidity and mortality has emerged as the leading cause of death for vasculitis patients. Cardiovascular events likely occur as a consequence of vasculitis, vascular damage from prior inflammation causing a sustained procoagulant state, and accelerated atherosclerosis. In this review, we discuss the latest evidence regarding risk of cardiovascular events in patients with major forms of primary systemic vasculitis, and review the mechanisms by which accelerated atherosclerosis may occur.
引用
收藏
页码:8 / 15
页数:8
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