Design of Polyphosphoester-DNA Nanoparticles for Non-Viral Gene Delivery

被引：38

作者：

Mao, Hai-Quan ^{[1
]}

Leong, Kam W. ^{[2
]}

机构：

[1] Johns Hopkins Med Inst, Dept Mat Sci & Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA

来源：

NON-VIRAL VECTORS FOR GENE THERAPY, 2ND EDITION: PART 1 | 2005年 / 53卷

关键词：

D O I：

10.1016/S0065-2660(05)53011-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Development of safe and effective non-viral gene carriers is still critical to the ultimate success of gene therapy. This review highlights our attempt to design the gene carriers in a systematic manner. We have synthesized a series of polymers with a phosphoester backbone containing different charge groups in the sidechain connected to the backbone through a phosphate (P-O) or a phosphoramide (P-N) bond. These gene carriers have different charge groups, sidechain lengths, and branching structures, but they are structurally related to allow a systematic investigation of the structure-property relationship, including DNA binding capacity, cytotoxicity, DNA protection, biodegradability, DNA release kinetics, and transfection efficiency. (C) 2005, Elsevier Inc.

引用

页码：275 / 306

页数：32

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