Circular dichroism study of chiral biomolecules conjugated nanoparticles

被引：111

作者：

Li, TH

Park, HG ^{[1
]}

Lee, HS

Choi, SH

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

[3] Hannam Univ, Dept Chem, Taejon 306901, South Korea

来源：

NANOTECHNOLOGY | 2004年 / 15卷 / 10期

关键词：

D O I：

10.1088/0957-4484/15/10/026

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Chiral biomolecules conjugated with silver nanoparticles were investigated by circular dichroism (CD) spectroscopy. Silver nanoparticles were prepared by the citrate reduction method and were characterized by UV spectroscopy and TEM. Conjugation of thiol group-containing biomolecules, such as cysteine, glutathione and penicillamine, with silver nanoparticles resulted in the generation of new characteristic CD signals in the region of 240-400 nm, whereas no CD signal changes were found with lysine or glutamine. Association through hydrogen bonding among the biomolecules is considered to be essential for CD signal generation, which was confirmed by experiment with cysteine methyl ester. Interestingly, Au nanoparticles were not found to generate CD signals in the wavelength region tested, indicating that this phenomenon is a unique feature of silver nanoparticles, distinguished from gold nanoparticles.

引用

页码：S660 / S663

页数：4

共 13 条

[1] A new insight into the Ag+ and Cu+ binding sites in the metallothionein β domain [J].