Haploidentical Donor Bone Marrow Transplantation for Severe Aplastic Anemia

被引：19
作者：
DeZern, Amy E. [1 ]
Brodsky, Robert A. [2 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Div Hematol Malignancies, 1650 Orleans St,CRBI Room 3M87, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sch Med, Div Hematol, 720 Rutland Ave,Ross 1025, Baltimore, MD 21205 USA
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2018年 / 32卷 / 04期
关键词：
Severe aplastic anemia; Cyclophosphamide; Haploidentical transplant; Graft versus host disease; STEM-CELL TRANSPLANTATION; HIGH-DOSE CYCLOPHOSPHAMIDE; VERSUS-HOST-DISEASE; ANTI-HLA ANTIBODIES; TERM-FOLLOW-UP; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; IMMUNOSUPPRESSIVE THERAPY; PERIPHERAL-BLOOD; ANTITHYMOCYTE GLOBULIN; PEDIATRIC-PATIENTS;
D O I：
10.1016/j.hoc.2018.04.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hematopoietic stem cell transplantation (bone marrow transplantation [BMT]) is the only curative treatment of severe aplastic anemia. BMT from a human leukocyte antigen (HLA)-matched sibling donor is the standard of care for young patients; immunosuppressive therapy is used for older patients or those lacking matched sibling donors. Patients with refractory or relapsed disease are increasingly treated with HLA haploidentical BMT. Historically, haploidentical BMT led to high rates of graft rejection and graft-versus-host disease. High-dose posttransplant cyclophosphamide, which mitigates the risk of graft-versus-host disease, is a major advance. This article provides an overview of the haploidentical BMT approach in severe aplastic anemia.
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收藏
页码：629 / +
页数：15
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