Using zebrafish to study the complex genetics of glaucoma

被引：41
作者：
McMahon, C
Semina, EV
Link, BA
机构：
[1] Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 2004年 / 138卷 / 03期
关键词：
anterior segment; complex disease; eye; FoxC1; glaucoma; Lmx1b; pitx; zebrafish;
D O I：
10.1016/j.cca.2004.03.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The overall goal of this review is to highlight the power of zebrafish as a model system for studying complex diseases which involve multiple genetic loci. We are interested in identifying and characterizing genes implicated in the blinding condition of glaucoma. Glaucoma is a complex disease that often involves multiple genetic loci. Most disease causing and modifying genes for glaucoma remain unidentified. However, several genes that regulate various aspects of ocular development have been shown to associate with glaucoma. With zebrafish, forward and reverse genetic approaches can be combined in order to identify critical genetic interactions required for normal and pathological events in the development and maintenance of the eye. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：343 / 350
页数：8
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