Prenatal Alcohol Exposure and Hypothalamic-Pituitary-Adrenal Axis Activity of the Offspring in Humans: a Systematic Review

被引：2

作者：

Diaz-Miranda, Elena ^{[1
]}

Nadal, Roser ^{[2
,3
,4
]}

Armario, Antonio ^{[2
,4
,5
]}

Labad, Javier ^{[4
,6
,7
]}

机构：

[1] Complejo Hosp Univ Insular Materno Infantil Las P, Las Palmas Gran Canaria, Spain

[2] Inst Neurociencies, Barcelona, Spain

[3] Univ Autonoma Barcelon, Fac Psychol, Pychobiol Unit, Barcelona, Spain

[4] CIBERSAM, Madrid, Spain

[5] Univ Autonoma Barcelona, Fac Biosci, Dept Cellular Biol Physiol & Immunol, Anim Physiol Unit, Barcelona, Spain

[6] Consorci Sanitari Maresme, Mataro, Spain

[7] Inst Invest & Innovacio Parc Tauli I3PT, Sabadell, Spain

来源：

CURRENT ADDICTION REPORTS | 2021年 / 8卷 / 01期

关键词：

Prenatal alcohol exposure; Prenatal stress; Cortisol; Pregnancy; Alcohol; EARLY-LIFE STRESS; SPECTRUM DISORDERS; SALIVARY CORTISOL; EARLY-CHILDHOOD; HAIR CORTISOL; REACTIVITY; CHILDREN; DEPRESSION; PREDICTOR; RESPONSES;

D O I：

10.1007/s40429-020-00349-1

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Purpose of Review We aimed to conduct a systematic review of studies exploring the relationship between prenatal alcohol exposure (PAE) and hypothalamic-pituitary-adrenal (HPA) axis functioning in the offspring in humans. Recent Findings Animal studies have demonstrated that PAE has long-term consequences in HPA axis activity in the offspring. Fewer studies have been conducted in humans. Our systematic review identified 9 studies including infants/toddlers (n = 6) and children/adolescents (n = 3). Cortisol responses to stress were only studied in infants/toddlers (3 studies: painful stressors; 3 studies: social stressors). In infants/toddlers, PAE seems to be associated with a blunted response to painful stressors whereas an enhanced cortisol response to social stress is observed (only in boys). In children/adolescents, the normal cortisol circadian rhythm is altered in PAE participants with a FASD diagnosis, who show increased evening cortisol levels. These findings support the programming effects of alcohol on the HPA stress system.

引用

页码：81 / 88

页数：8

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