Biomarker Use for Dementia With Lewy Body Diagnosis: Survey of US Experts

被引：13

作者：

Armstrong, Melissa J. ^{[1
]}

Irwin, David J. ^{[3
]}

Leverenz, James B. ^{[4
]}

Gamez, Noheli ^{[1
]}

Taylor, Angela ^{[5
]}

Galvin, James E. ^{[2
]}

机构：

[1] Univ Florida, Coll Med, Dept Neurol, McKnight Brain Inst, Gainesville, FL 32611 USA

[2] Univ Miami, Miller Sch Med, Dept Neurol, Comprehens Ctr Brain Hlth, Miami, FL 33136 USA

[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[4] Cleveland Clin, Cleveland Lou Ruvo Ctr Brain Hlth, Neurol Inst, Cleveland, OH 44106 USA

[5] Lewy Body Dementia Assoc, Lilburn, GA USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2021年 / 35卷 / 01期

关键词：

dementia with Lewy bodies; Lewy body disease; diagnosis; biomarkers; diagnostic tests; routine;

D O I：

10.1097/WAD.0000000000000414

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Dementia with Lewy body (DLB) diagnostic criteria define "indicative" and "supportive" biomarkers, but clinical practice patterns are unknown. Methods: An anonymous survey querying clinical use of diagnostic tests/biomarkers was sent to 38 center of excellence investigators. The survey included "indicative" biomarkers (dopamine transporter scan, myocardial scintigraphy, polysomnography), "supportive" biomarkers [magnetic resonance imaging (MRI)], positron emission tomography, or single-photon emission computed tomography perfusion/metabolism scans, quantitative electroencephalography), and other diagnostic tests (neuropsychological testing, cerebrospinal fluid analysis, genetics). Responses were analyzed descriptively. Results: Of the 22 respondents (58%), all reported the capability to perform neuropsychological testing, MRI, polysomnography, dopamine transporter scans, positron emission tomography/single-photon emission computed tomography scans, and cerebrospinal fluid analysis; 96% could order genetic testing. Neuropsychological testing and MRI were the most commonly ordered tests. Diagnostic testing beyond MRI and neuropsychological testing was most helpful in the context of "possible" DLB and mild cognitive impairment and to assist with differential diagnosis. Myocardial scintigraphy and electroencephalograpy use were rare. Conclusions and Relevance: Neuropsychological testing and MRI remain the most widely used diagnostic tests by DLB specialists. Other tests-particularly indicative biomarkers-are used only selectively. Research is needed to validate existing potential DLB biomarkers, develop new biomarkers, and investigate mechanisms to improve DLB diagnosis.

引用

页码：55 / 61

页数：7

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