Noncovalent Self-Assembled Smart Gold(III) Porphyrin Nanodrug for Synergistic Chemo-Photothermal Therapy

被引：44

作者：

Wang, Xiao ^{[1
]}

Wang, Jiefei ^{[2
]}

Wang, Jinghan ^{[1
]}

Zhong, Yong ^{[1
]}

Han, Lulu ^{[2
]}

Yan, Jiliang ^{[2
]}

Duan, Pengcheng ^{[1
]}

Shi, Bingyang ^{[1
]}

Bai, Feng ^{[1
]}

机构：

[1] Henan Univ, Natl & Local Joint Engn Res Ctr High Efficiency D, Collaborat Innovat Ctr Nano Funct Mat & Applicat, Sch Mat Sci & Engn,Key Lab Special Funct Mat,Mini, Kaifeng 475004, Peoples R China

[2] Henan Univ, Henan & Macquarie Univ Joint Ctr Biomed Innovat, Sch Life Sci, Kaifeng 475004, Peoples R China

来源：

NANO LETTERS | 2021年 / 21卷 / 08期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

dual stimuli; gold porphyrin; metalation; self-assembly; synergistic therapy; IN-VITRO; NANOPARTICLES; APOPTOSIS; CISPLATIN; DELIVERY; COMPLEX; GROWTH;

D O I：

10.1021/acs.nanolett.0c04915

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Self-assembly is a powerful means to fabricate multifunctional smart nanotheranostics. However, the complicated preparation, toxicity of responsive carriers, and low loading efficiency of drug cargo hinder the outcome. Herein, we developed a responsive carrier-free noncovalent self-assembly strategy of a metallized Au(III) tetra-(4-pyridyl) porphine (AuTPyP) anticancer drug for the preparation of a heat/acid dual-stimulated nanodrug, and it generated a better photothermal effect than monomers under irradiation. The photothermal effect promoted the protonation of the hydrophobic pyridyl group and the following release into tumorous acidic microenvironments. With cRGD modification, the released drug induced the aggravation of intracellular reactive oxygen species (ROS) via the activity inhibition of thioredoxin reductase (TrxR) for synergistic chemo-photothermal therapy of tumors.

引用

页码：3418 / 3425

页数：8

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