Two period homologs:: Circadian expression and photic regulation in the suprachiasmatic nuclei

被引：635
作者：
Shearman, LP
Zylka, MJ
Weaver, DR
Kolakowski, LF
Reppert, SM [1 ]
机构：
[1] Massachusetts Gen Hosp, Lab Dev Chronobiol Pediat Serv, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA
[4] Univ Texas, Hlth Sci Ctr, Dept Pharmacol, San Antonio, TX 78284 USA
来源：
NEURON | 1997年 / 19卷 / 06期
关键词：
D O I：
10.1016/S0896-6273(00)80417-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have characterized a mammalian homolog of the Drosophila period gene and designated it Per?. The PERS protein shows >40% amino acid identity to the protein of another mammalian per homolog (designated Per1) that was recently cloned and characterized. Both PER1 and PER2 proteins share several regions of homology with the Drosophila PER protein, including the protein dimerization PAS domain. Phylogenetic analysis supports the existence of a family of mammalian per genes. In the mouse, Per1 and Per2 RNA levels exhibit circadian rhythms in the SCN and eyes, sites of circadian clocks. Both Per1 and Per2 RNAs in the SCN are increased by light exposure during subjective night but not during subjective day. The results advance our knowledge of candidate clock elements in mammals.
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页码：1261 / 1269
页数：9
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