Ten thousand interactions for the molecular biologist

被引：143
作者：
Aloy, P
Russell, RB
机构：
[1] EMBL, D-69117 Heidelberg, Germany
[2] EMBL, European Bioinformat Inst, Cambridge CB10 1SD, England
来源：
NATURE BIOTECHNOLOGY | 2004年 / 22卷 / 10期
关键词：
D O I：
10.1038/nbt1018
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Previous studies have suggested that nature is restricted to about 1,000 protein folds to perform a great diversity of functions. Here, we use protein interaction data from different sources and three-dimensional structures to suggest that the total number of interaction types is also limited, and estimate that most interactions in nature will conform to one of about 10,000 types. We currently know fewer than 2,000, and at the present rate of structure determination, it will be more than 20 years before we know a full representative set.
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页码：1317 / 1321
页数：5
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