Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets

被引：46
作者：
Ashford, Bruce G. [1 ,2 ,3 ,4 ]
Clark, Jonathan [5 ,6 ,7 ]
Gupta, Ruta [8 ,9 ]
Iyer, N. Gopalakrishna [10 ]
Yu, Bing [9 ,11 ]
Ranson, Marie [2 ,4 ,12 ]
机构：
[1] Univ Wollongong, Sch Biol Sci, Northfields Ave, Wollongong, NSW, Australia
[2] IHMRI, Northfields Ave, Wollongong, NSW 2522, Australia
[3] ISLHD, Loftus St, Wollongong, NSW 2500, Australia
[4] Ctr Oncol Educ & Res Translat CONCERT, Liverpool, NSW 2170, Australia
[5] Chris OBrien Lifehouse, Sydney Head & Neck Canc Inst, Dept Head & Neck Surg, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia
[6] Univ Sydney, Cent Clin Sch, Sydney, NSW 2006, Australia
[7] Univ New South Wales, South Western Clin Sch, Goulburn St, Liverpool, NSW 2170, Australia
[8] Royal Prince Alfred Hosp, Dept Tissue Pathol & Diagnost Oncol, Missenden Rd, Camperdown, NSW 2050, Australia
[9] Univ Sydney, Sydney, NSW 2006, Australia
[10] NCCS, Singhlth Duke NUS Head & Neck Ctr, 11 Hosp Dr, Singapore 169610, Singapore
[11] Royal Prince Alfred Hosp, Dept Tissue Pathol & Diagnost Oncol, Missenden Rd, Camperdown, NSW 2050, Australia
[12] Univ Wollongong, Sch Biol Sci, Northfields Ave, Wollongong, NSW 2522, Australia
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 07期
关键词：
carcinoma; genomic; high risk; metastasis; skin; MUTATIONS; HEAD; CANCER; EXPRESSION; METASTASES; DENSITY; EMT; P53;
D O I：
10.1002/hed.24765
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Cutaneous squamous cell carcinoma (SCC) is second only in incidence to basal cell carcinoma (BCC), effecting up to 500000 people in the United States annually. Metastasis to regional lymph nodes occurs in approximately 5% of cases and imparts significant morbidity. Standard treatment in this group involves a combination of surgery and adjuvant radiation. Currently, there are no clinically useful biomarkers of metastatic potential in primary cutaneous SCC and histological predictors can be unreliable. The high level of mutational burden in normal UV-exposed skin has hampered the search for novel drivers of invasive disease, and indeed metastatic potential. This review outlines the clinical problems in high-risk and metastatic cutaneous SCCs, reviews the known genetic events and molecular mechanisms in high-risk primary cutaneous SCC and metastasis, and identifies avenues for further investigation and potential therapy.
引用
收藏
页码：1462 / 1469
页数：8
相关论文
共 39 条
[21]   CDKN2A but not TP53 mutations nor HPV presence predict poor outcome in metastatic squamous cell carcinoma of the skin [J].
Kusters-Vandevelde, Heidi V. N. ;
Van Leeuwen, Arjanne ;
Verdijk, Marian A. J. ;
de Koning, Maurits N. C. ;
Quint, Wim G. V. ;
Melchers, Willem J. G. ;
Ligtenberg, Marjolijn J. L. ;
Blokx, Willeke A. M. .
INTERNATIONAL JOURNAL OF CANCER, 2010, 126 (09) :2123-2132
[22]   Molecular mechanisms of epithelial-mesenchymal transition [J].
Lamouille, Samy ;
Xu, Jian ;
Derynck, Rik .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (03) :178-196
[23]   Inhibition of uPAR-TGFβ crosstalk blocks MSC-dependent EMT in melanoma cells [J].
Laurenzana, Anna ;
Biagioni, Alessio ;
Bianchini, Francesca ;
Peppicelli, Silvia ;
Chilla, Anastasia ;
Margheri, Francesca ;
Luciani, Cristina ;
Pimpinelli, Nicola ;
Del Rosso, Mario ;
Calorini, Lido ;
Fibbi, Gabriella .
JOURNAL OF MOLECULAR MEDICINE-JMM, 2015, 93 (07) :783-794
[24]   Genomic Analysis of Metastatic Cutaneous Squamous Cell Carcinoma [J].
Li, Yvonne Y. ;
Hanna, Glenn J. ;
Laga, Alvaro C. ;
Haddad, Robert I. ;
Lorch, Jochen H. ;
Hammerman, Peter S. .
CLINICAL CANCER RESEARCH, 2015, 21 (06) :1447-1456
[25]   Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer [J].
Lui, Vivian Wai Yan ;
Peyser, Noah D. ;
Ng, Patrick Kwok-Shing ;
Hritz, Jozef ;
Zeng, Yan ;
Lu, Yiling ;
Li, Hua ;
Wang, Lin ;
Gilbert, Breean R. ;
General, Ignacio J. ;
Bahar, Ivet ;
Ju, Zhenlin ;
Wang, Zhenghe ;
Pendleton, Kelsey P. ;
Xiao, Xiao ;
Du, Yu ;
Vries, John K. ;
Hammerman, Peter S. ;
Garraway, Levi A. ;
Mills, Gordon B. ;
Johnson, Daniel E. ;
Grandis, Jennifer R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (03) :1114-1119
[26]   High burden and pervasive positive selection of somatic mutations in normal human skin [J].
Martincorena, Inigo ;
Roshan, Amit ;
Gerstung, Moritz ;
Ellis, Peter ;
Van Loo, Peter ;
McLaren, Stuart ;
Wedge, David C. ;
Fullam, Anthony ;
Alexandrov, Ludmil B. ;
Tubio, Jose M. ;
Stebbings, Lucy ;
Menzies, Andrew ;
Widaa, Sara ;
Stratton, Michael R. ;
Jones, Philip H. ;
Campbell, Peter J. .
SCIENCE, 2015, 348 (6237) :880-886
[27]   Low incidence of EGFR and HRAS mutations in cutaneous squamous cell carcinomas of a German cohort [J].
Mauerer, Andreas ;
Herschberger, Eva ;
Dietmaier, Wolfgang ;
Landthaler, Michael ;
Hafner, Christian .
EXPERIMENTAL DERMATOLOGY, 2011, 20 (10) :848-850
[28]   Multiple roles of notch signaling in the regulation of epidermal development [J].
Moriyama, Mariko ;
Durham, Andre-Dante ;
Moriyama, Hiroyuki ;
Hasegawa, Kiyotaka ;
Nishikawa, Shin-Ichi ;
Radtke, Freddy ;
Osawa, Masatake .
DEVELOPMENTAL CELL, 2008, 14 (04) :594-604
[29]   The Human Cutaneous Squamous Cell Carcinoma Microenvironment Is Characterized by Increased Lymphatic Density and Enhanced Expression of Macrophage-Derived VEGF-C [J].
Moussai, Dariush ;
Mitsui, Hiroshi ;
Pettersen, Julia S. ;
Pierson, Katherine C. ;
Shah, Kejal R. ;
Suarez-Farinas, Mayte ;
Cardinale, Irma R. ;
Bluth, Mark J. ;
Krueger, James G. ;
Carucci, John A. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (01) :229-236
[30]   Risk stratification for metastasis from cutaneous squamous cell carcinoma of the head and neck [J].
Peat, Bruce ;
Insull, Phillip ;
Ayers, Rebecca .
ANZ JOURNAL OF SURGERY, 2012, 82 (04) :230-233
1234