Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets

被引：46
作者：
Ashford, Bruce G. [1 ,2 ,3 ,4 ]
Clark, Jonathan [5 ,6 ,7 ]
Gupta, Ruta [8 ,9 ]
Iyer, N. Gopalakrishna [10 ]
Yu, Bing [9 ,11 ]
Ranson, Marie [2 ,4 ,12 ]
机构：
[1] Univ Wollongong, Sch Biol Sci, Northfields Ave, Wollongong, NSW, Australia
[2] IHMRI, Northfields Ave, Wollongong, NSW 2522, Australia
[3] ISLHD, Loftus St, Wollongong, NSW 2500, Australia
[4] Ctr Oncol Educ & Res Translat CONCERT, Liverpool, NSW 2170, Australia
[5] Chris OBrien Lifehouse, Sydney Head & Neck Canc Inst, Dept Head & Neck Surg, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia
[6] Univ Sydney, Cent Clin Sch, Sydney, NSW 2006, Australia
[7] Univ New South Wales, South Western Clin Sch, Goulburn St, Liverpool, NSW 2170, Australia
[8] Royal Prince Alfred Hosp, Dept Tissue Pathol & Diagnost Oncol, Missenden Rd, Camperdown, NSW 2050, Australia
[9] Univ Sydney, Sydney, NSW 2006, Australia
[10] NCCS, Singhlth Duke NUS Head & Neck Ctr, 11 Hosp Dr, Singapore 169610, Singapore
[11] Royal Prince Alfred Hosp, Dept Tissue Pathol & Diagnost Oncol, Missenden Rd, Camperdown, NSW 2050, Australia
[12] Univ Wollongong, Sch Biol Sci, Northfields Ave, Wollongong, NSW 2522, Australia
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 07期
关键词：
carcinoma; genomic; high risk; metastasis; skin; MUTATIONS; HEAD; CANCER; EXPRESSION; METASTASES; DENSITY; EMT; P53;
D O I：
10.1002/hed.24765
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Cutaneous squamous cell carcinoma (SCC) is second only in incidence to basal cell carcinoma (BCC), effecting up to 500000 people in the United States annually. Metastasis to regional lymph nodes occurs in approximately 5% of cases and imparts significant morbidity. Standard treatment in this group involves a combination of surgery and adjuvant radiation. Currently, there are no clinically useful biomarkers of metastatic potential in primary cutaneous SCC and histological predictors can be unreliable. The high level of mutational burden in normal UV-exposed skin has hampered the search for novel drivers of invasive disease, and indeed metastatic potential. This review outlines the clinical problems in high-risk and metastatic cutaneous SCCs, reviews the known genetic events and molecular mechanisms in high-risk primary cutaneous SCC and metastasis, and identifies avenues for further investigation and potential therapy.
引用
收藏
页码：1462 / 1469
页数：8
相关论文
共 39 条
[1]   Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].
Agrawal, Nishant ;
Frederick, Mitchell J. ;
Pickering, Curtis R. ;
Bettegowda, Chetan ;
Chang, Kyle ;
Li, Ryan J. ;
Fakhry, Carole ;
Xie, Tong-Xin ;
Zhang, Jiexin ;
Wang, Jing ;
Zhang, Nianxiang ;
El-Naggar, Adel K. ;
Jasser, Samar A. ;
Weinstein, John N. ;
Trevino, Lisa ;
Drummond, Jennifer A. ;
Muzny, Donna M. ;
Wu, Yuanqing ;
Wood, Laura D. ;
Hruban, Ralph H. ;
Westra, William H. ;
Koch, Wayne M. ;
Califano, Joseph A. ;
Gibbs, Richard A. ;
Sidransky, David ;
Vogelstein, Bert ;
Velculescu, Victor E. ;
Papadopoulos, Nickolas ;
Wheeler, David A. ;
Kinzler, Kenneth W. ;
Myers, Jeffrey N. .
SCIENCE, 2011, 333 (6046) :1154-1157
[2]   Primary care: Cutaneous squamous-cell carcinoma [J].
Alam, M ;
Ratner, D .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (13) :975-983
[3]   The epidemiology of UV induced skin cancer [J].
Armstrong, BK ;
Kricker, A .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2001, 63 (1-3) :8-18
[4]   Ambivalent role of pFAK-Y397 in serous ovarian cancer- a study of the OVCAD consortium [J].
Aust, Stefanie ;
Auer, Katharina ;
Bachmayr-Heyda, Anna ;
Denkert, Carsten ;
Sehouli, Jalid ;
Braicu, Ioana ;
Mahner, Sven ;
Lambrechts, Sandrina ;
Vergote, Ignace ;
Grimm, Christoph ;
Horvat, Reinhard ;
Castillo-Tong, Dan Cacsire ;
Zeillinger, Robert ;
Pils, Dietmar .
MOLECULAR CANCER, 2014, 13
[5]   Prognostic Significance of Vascular Endothelial Growth Factor-C Expression and Lymphatic Vessel Density in Supraglottic Squamous Cell Carcinoma [J].
Baek, Seung-Kuk ;
Jung, Kwang-Yoon ;
Lee, Sang-Hag ;
Woo, Jeong-Soo ;
Kwon, Soon-Young ;
Chung, Eun-Jae ;
Kim, Tae-Hoon ;
Chae, Yang-Seok .
LARYNGOSCOPE, 2009, 119 (07) :1325-1330
[6]   Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas [J].
Botti, Elisabetta ;
Spallone, Giulia ;
Moretti, Francesca ;
Marinari, Barbara ;
Pinetti, Valentina ;
Galanti, Sergio ;
De Meo, Paolo D'Onorio ;
De Nicola, Francesca ;
Ganci, Federica ;
Castrignano, Tiziana ;
Pesole, Graziano ;
Chimenti, Sergio ;
Guerrini, Luisa ;
Fanciulli, Maurizio ;
Blandino, Giovanni ;
Karin, Michael ;
Costanzo, Antonio .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (33) :13710-13715
[7]   Analysis of risk factor's determining prognosis of cutaneous squamous-cell carcinoma:: a prospective study [J].
Brantsch, Kay D. ;
Meisner, Christoph ;
Schoenfisch, Birgitt ;
Trilling, Birgit ;
Wehner-Caroli, Joerg ;
Roecken, Martin ;
Breuninger, Helmut .
LANCET ONCOLOGY, 2008, 9 (08) :713-720
[8]   Distant metastases from cutaneous squamous cell carcinoma-analysis of AJCC stage IV [J].
Brunner, Markus ;
Veness, Michael J. ;
Ch'ng, Sydney ;
Elliott, Michael ;
Clark, Jonathan R. .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2013, 35 (01) :72-75
[9]   The multi-step process of human skin carcinogenesis:: A role for p53, cyclin D1, hTERT, p16, and TSP-1 [J].
Burnworth, Bettina ;
Arendt, Susanne ;
Muffler, Sonja ;
Steinkraus, Volker ;
Broecker, Eva B. ;
Birek, Catalina ;
Hartschuh, Wolfgang ;
Jauch, Anna ;
Boukamp, Petra .
EUROPEAN JOURNAL OF CELL BIOLOGY, 2007, 86 (11-12) :763-780
[10]   Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma [J].
Ch'ng, Sydney ;
Clark, Jonathan R. ;
Brunner, Markus ;
Palme, Carsten E. ;
Morgan, Gary J. ;
Veness, Michael J. .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2013, 35 (02) :190-194
1234