Inhibition of fucosyl transferase and fucosidase by a rigid bicyclic mimic of α-L-fucose

被引：21

作者：

Beacham, AR

Smelt, KH

Biggadike, K

Britten, CJ

Hackett, L

Winchester, BG

Nash, RJ

Griffiths, RC

Fleet, GWJ

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

[3] Inst Child Hlth, Div Biochem & Genet, London WC1N 1EH, England

[4] AFRC, Inst Grassland & Environm Res, Aberystwyth SY23 3EB, Dyfed, Wales

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 1-2期

关键词：

D O I：

10.1016/S0040-4039(97)10473-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rigid bicyclic analogue of a-L-fucose, prepared from a monoacetonide of L-gulonolactone in an overall yield of 36% without the need for column chromatography, is a potent inhibitor of fucosidases and a weak inhibitor of a fucosyl transferase. (C) 1997 Elsevier Science Ltd. All rights reserved.

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收藏

页码：151 / 154

页数：4

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