Surface, aggregation properties and antimicrobial activity of four novel thiourea-based non-ionic surfactants

被引：30

作者：

Ullah, Imdad ^{[1
,2
]}

Shah, Afzal ^{[1
,2
,3
]}

Badshah, Amin ^{[2
]}

Shah, Afzal ^{[1
,2
,3
]}

Shah, Naseer Ali ^{[2
]}

Tabor, Rico ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Melbourne, Vic 3800, Australia

[2] Quaid I Azam Univ, Dept Chem, Islamabad 45300, Pakistan

[3] Univ Sci & Technol, Dept Chem, Bannu 28100, Khyber Pakhtunk, Pakistan

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2015年 / 464卷

关键词：

Synthesis; Non-ionic surfactants; Critical micelle concentration; Antibacterial and antifungal activities;

D O I：

10.1016/j.colsurfa.2014.10.002

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Four novel thiourea-based non-ionic surfactants, 1-decanoyl-3-phenylthiourea, 1-decanoyl-3-ethylthiourea, 1-butyl-3-decanoylthiourea and 1-cyclohexyl-3-decanoylthiourea were synthesized from readily available synthetic building blocks in high yield. The compounds were characterized by H-1 NMR, C-13 NMR, FTIR and UV-Visible spectrophotometry. These surfactants show very low solubility in water, and interestingly low, but well-defined sub-millimolar critical micelle concentrations (CMCs) in ethanol and toluene, indicating that they are moderately amphiphobic. The antibacterial activity of the synthesized thiourea-based surfactants was tested against five bacterial strains, as well as the antifungal activity against five fungal strains. In all cases, the inhibition of bacterial and fungal growth was significant for all of the synthesized molecules. These molecules are particularly desirable for antimicrobial functionalization of surfaces due to their facile synthesis and their low water solubility, providing robust coatings in aqueous environments. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：104 / 109

页数：6

共 26 条

[1] Synthesis and biological evaluation of some new coumarin derivatives [J].