Treatment of contaminated soil with phosphorus and manganese oxide reduces lead absorption by Sprague-Dawley rats

被引:55
作者
Hettiarachchi, GM
Pierzynski, GM
Oehme, FW
Sonmez, O
Ryan, JA
机构
[1] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45224 USA
[2] Kansas State Univ, Dept Agron, Manhattan, KS 66506 USA
[3] Kansas State Univ, Comparat Toxicol Labs, Manhattan, KS 66506 USA
关键词
D O I
10.2134/jeq2003.1335
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This study was conducted to determine the extent of Pb absorption into young rats (Rattus norvegicus var. Sprague-Dawley) fed untreated Pb-contaminated soil or Pb-contaminated soil treated with two different sources of P and P + Mn oxide. Data were compared from an in vitro, physiologically based extraction test (PBET) with the animal data to support the validity of the in vitro test to assess bioavailable Pb from a treated Pb-contaminated soil. Soil with a total Pb concentration of 2290 mg kg(-1) was used. Rats were fed 19 different test diets for 21 consecutive days. The test diets represented 95 g AIN93G rat meal kg(-1) diet with varying proportions of silica sand or soil to provide low, medium, or high doses of Pb from either Pb acetate, treated, or untreated soil. Blood, liver, kidney, and bone Pb concentrations were examined. For all four tissues, Pb concentrations for the Pb acetate groups were significantly higher than concentrations for all the soil groups. In general, either triple superphosphate (TSP) or phosphate rock (PR) treatments resulted in significant reductions in tissue Ph concentrations compared with untreated soil. Blood and kidney Pb concentrations for the PR + Mn oxide group were significantly lower than those of the PR group at the low and high doses. Relative bioavailability of pb, as measured in all tissues, was significantly reduced when comparing untreated with amended soil. Correlation between the in vitro and in vivo tests, based on bone and liver tissue, showed that the in vitro test is successful at predicting Ph bioavailability.
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页码:1335 / 1345
页数:11
相关论文
共 40 条
[1]   THE EFFECTS OF DIETARY CALCIUM ON LEAD ABSORPTION, DISTRIBUTION, AND ELIMINATION KINETICS IN RATS [J].
AUNGST, BJ ;
FUNG, HL .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1985, 16 (01) :147-159
[2]  
BARTON JC, 1978, J LAB CLIN MED, V91, P366
[3]  
BARTON JC, 1978, J LAB CLIN MED, V92, P536
[4]  
Brown S.L., 1999, P 5 INT C BIOG TRAC, P506
[5]   Bioavailability of lead to juvenile swine dosed with soil from the Smuggler Mountain NPL site of Aspen, Colorado [J].
Casteel, SW ;
Cowart, RP ;
Weis, CP ;
Henningsen, GM ;
Hoffman, E ;
Brattin, WJ ;
Guzman, RE ;
Starost, MF ;
Payne, JT ;
Stockham, SL ;
Becker, SV ;
Drexler, JW ;
Turk, JR .
FUNDAMENTAL AND APPLIED TOXICOLOGY, 1997, 36 (02) :177-187
[6]  
Chaney R.L., 1989, Proc Int Conf on Lead in Soils: Issues and Guidelines, V11, P105
[7]  
CHANEY RL, 1991, P S BIOAV DIET UPT L
[8]  
CONRAD ME, 1978, GASTROENTEROLOGY, V74, P731
[9]   Remediation of contaminated land by formation of heavy metal phosphates [J].
CotterHowells, J ;
Caporn, S .
APPLIED GEOCHEMISTRY, 1996, 11 (1-2) :335-342
[10]   IDENTIFICATION OF PYROMORPHITE IN MINE-WASTE CONTAMINATED SOILS BY ATEM AND EXAFS [J].
COTTERHOWELLS, JD ;
CHAMPNESS, PE ;
CHARNOCK, JM ;
PATTRICK, RAD .
EUROPEAN JOURNAL OF SOIL SCIENCE, 1994, 45 (04) :393-402