Urinary bladder cancer as a late sequela of spinal cord injury Decision-making aids for assessment of this causal association

被引:6
作者
Boethig, R. [1 ]
Schoeps, W.
Zellner, M. [2 ]
Fiebag, K. [1 ]
Kowald, B. [3 ]
Hirschfeld, S. [4 ]
Thietje, R. [4 ]
Kurze, I. [5 ]
Boehme, H. [6 ]
Kaufmann, A. [7 ]
Jungmann, O. [8 ]
Zumbe, J. [9 ]
Porres, D. [9 ]
Luemmen, G. [10 ]
Nehiba, M. [11 ]
Kadhum, T. [12 ,13 ]
Forchert, M. [14 ]
Golka, K. [12 ]
机构
[1] BG Klinikum Hamburg, Abt Neurourol, Querschnittgelahmten Zentrum, Bergedorfer Str 10, D-21033 Hamburg, Germany
[2] Johannesbad Fachklin, Abt Urol & Neurourol, Bad Fussing, Germany
[3] BG Klinikum Hamburg, Biomech Lab, Hamburg, Germany
[4] BG Klinikum Hamburg, Querschnittgelahmten Zentrum, Hamburg, Germany
[5] Querschnittgelahmten Zentrum, Zent Klin Bad Berka, Klin Paraplegiol & Neurourol, Bad Berka, Germany
[6] Asklepios Klin Barmbek, Urol Klin, Hamburg, Germany
[7] Kliniken Maria Hilf GmbH, Zentrum Kontinenz & Neurourol, Krankenhaus St Franziskus, Monchengladbach, Germany
[8] Malteser Krankenhaus St Hildegardis, Urol Klin Lindenthal, Cologne, Germany
[9] Klinikum Leverkusen, Urol Klin, Leverkusen, Germany
[10] St Josef Hosp, Urol Abt, Betriebsstatte St Josef Troisdorf, GFO Kliniken Troisdorf, Troisdorf, Germany
[11] Werner Wicker Klin, Abt Neurourol, Bad Wildungen, Germany
[12] TU Dortmund IfADo, Zent Einrichtung Klin Arbeitsmed, Leibniz Inst Arbeitsforsch, Dortmund, Germany
[13] Mittelrhein Klin Fachklin Psychosomat Rehabil, Boppard, Bad Salzig, Germany
[14] Stabsstelle UV Recht, Berufsgenossenschaft Holz & Met, Bielefeld, Germany
来源
UROLOGE | 2020年 / 59卷 / 06期
关键词
Neurogenic bladder; Transitional cell carcinoma; Squamous cell carcinoma; Survival time; Accident consequences; NEUROGENIC BLADDER; 2ND MALIGNANCIES; CELL CARCINOMA; RISK; RADIOTHERAPY; INDIVIDUALS; PARAPLEGIA; MANAGEMENT; THERAPY; SMOKING;
D O I
10.1007/s00120-020-01124-w
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background There is to date no convincing literature that has assessed the association between traumatic spinal cord injury (SCI) and the later development of urinary bladder cancer. The aim of this work is to present medical experts as well as the national accident insurance and the social courts decision-making aids based on the latest medical scientific knowledge, for assessment of this causal association. Materials and methods A study conducted between April 1998 and March 2017 in the BG Trauma Hospital Hamburg forms the basis for the decision-making aids. Urinary bladder cancer was diagnosed in 32 out of 6432 treated outpatient and inpatient SCI patients. Furthermore, relevant published literature was taken into consideration for the decision-making aids. Results It was found that urinary bladder cancer in SCI patients occurs at a considerably younger age as compared to the general population, more frequently shows muscle invasive carcinoma with a higher grade at first diagnosis and a higher proportion of the more aggressive squamous cell carcinoma than that of the general population. Correspondingly, the survival time is extremely unfavorable. For medical experts a matrix was compiled where the various influencing factors, either for or against the recognition of an association between SCI and urinary bladder cancer, were weighted according to their relevance. Conclusion The results showed that urinary bladder cancer in SCI patients differs considerably from that of able-bodied patients. These differences drastically shorten the survival time. A study on patients with spina bifida, i.e., a congenital spinal cord disorder, corroborates these observations. They indicate histopathological differences that have so far been intangible.
引用
收藏
页码:700 / 709
页数:10
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