Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction

被引：280
作者：
Basson, MA
Akbulut, S
Watson-Johnson, J
Simon, R
Carroll, TJ
Shakya, R
Gross, I
Martin, GR
Lufkin, T
McMahon, AP
Wilson, PD
Costantini, FD
Mason, IJ
Licht, JD
机构：
[1] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Brookdale Dept Mol Cell & Dev Biol, New York, NY 10029 USA
[3] Kings Coll London, MRC, Ctr Dev Neurobiol, London SE1 1UL, England
[4] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
[5] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[6] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA
来源：
DEVELOPMENTAL CELL | 2005年 / 8卷 / 02期
关键词：
D O I：
10.1016/j.devcel.2004.12.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Intercellular signaling molecules and their receptors, whose expression must be tightly regulated in time and space, coordinate organogenesis. Regulators of intracellular signaling pathways provide an additional level of control. Here we report that loss of the receptor tyrosine kinase (RTK) antagonist, Sprouty1 (Spry1), causes defects in kidney development in mice. Spry1-/- embryos have supernumerary ureteric buds, resulting in the development of multiple ureters and multiplex kidneys. These defects are due to increased sensitivity of the Wolffian duct to GDNF/RET signaling, and reducing Gdnf gene dosage correspondingly rescues the Spry1 null phenotype. We conclude that the function of Spry1 is to modulate GDNF/RET signaling in the Wolffian duct, ensuring that kidney induction is restricted to a single site. These results demonstrate the importance of negative feedback regulation of RTK signaling during kidney induction and suggest that failures in feedback control may underlie some human congenital kidney malformations.
引用
收藏
页码：229 / 239
页数：11
相关论文
共 67 条
[1]   The organizer factors Chordin and Noggin are required for mouse forebrain development [J].
Bachiller, D ;
Klingensmith, J ;
Kemp, C ;
Belo, JA ;
Anderson, RM ;
May, SR ;
McMahon, JA ;
McMahon, AP ;
Harland, RM ;
Rossant, J ;
De Robertis, EM .
NATURE, 2000, 403 (6770) :658-661
[2]   Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret [J].
Batourina, E ;
Choi, C ;
Paragas, N ;
Bello, N ;
Hensle, T ;
Costantini, FD ;
Schuchardt, A ;
Bacallao, RL ;
Mendelsohn, CL .
NATURE GENETICS, 2002, 32 (01) :109-115
[3]  
Brophy PD, 2001, DEVELOPMENT, V128, P4747
[4]   GFRα1 is an essential receptor component for GDNF in the developing nervous system and kidney [J].
Cacalano, G ;
Fariñas, I ;
Wang, LC ;
Hagler, K ;
Forgie, A ;
Moore, M ;
Armanini, M ;
Phillips, H ;
Ryan, AM ;
Reichardt, LF ;
Hynes, M ;
Davies, A ;
Rosenthal, A .
NEURON, 1998, 21 (01) :53-62
[5]   Sprouty, an intracellular inhibitor of Ras signaling [J].
Casci, T ;
Vinós, J ;
Freeman, M .
CELL, 1999, 96 (05) :655-665
[6]   Differential display of genes expressed at the midbrain-hindbrain junction identifies sprouty2:: An FGF8-inducible member of a family of intracellular FGF antagonists [J].
Chambers, D ;
Medhurst, AD ;
Walsh, FS ;
Price, J ;
Mason, I .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 15 (01) :22-35
[7]   Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling [J].
Chambers, D ;
Mason, I .
MECHANISMS OF DEVELOPMENT, 2000, 91 (1-2) :361-364
[8]   Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development [J].
Chi, LJ ;
Zhang, SB ;
Lin, YF ;
Prunskaite-Hyyryläinen, R ;
Vuolteenaho, R ;
Itäranta, P ;
Vainio, S .
DEVELOPMENT, 2004, 131 (14) :3345-3356
[9]   Split personalities: the agonistic antagonist Sprouty [J].
Christofori, G .
NATURE CELL BIOLOGY, 2003, 5 (05) :377-379
[10]   Spatial and temporal patterns of ERK signaling during mouse embryogenesis [J].
Corson, LB ;
Yamanaka, Y ;
Lai, KMV ;
Rossant, J .
DEVELOPMENT, 2003, 130 (19) :4527-4537
1234567