Rapid synthesis of acyl transfer auxiliaries for cysteine-free native glycopeptide ligation

被引：85
|
作者：
Macmillan, D [1 ]
Anderson, DW [1 ]
机构：
[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 25期
关键词：
D O I：
10.1021/ol048145o
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Rapid, facile routes to the TFA-cleavable 4,5,6-trimethoxy-2-mercaptobenzyl and 1-(2,4-dimethoxyphenyl)-2-mercaptoethyl classes of auxiliaries for cysteine-free native chemical ligation are described. Rapid synthesis, coupled with mild cleavage conditions will undoubtedly broaden the utility of such auxiliaries, particularly where chemically fragile peptide modifications such as glycosylation are present.
引用
收藏
页码：4659 / 4662
页数：4
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