New polyhydroxylated sterols stylisterols A-C and a novel 5,19-cyclosterol hatomasterol from the Okinawan marine sponge Stylissa sp.

被引：16
作者：
Mitome, H
Shirato, N
Hoshino, A
Miyaoka, H
Yamada, Y
Van Soest, RWM
机构：
[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan
[2] Univ Amsterdam, Inst Systemat & Ecol, NL-1090 GT Amsterdam, Netherlands
来源：
STEROIDS | 2005年 / 70卷 / 01期
关键词：
sterols; sponge; Stylissa sp; marine metabolites; polyhydroxylated sterols; 5,19-cyclosterol;
D O I：
10.1016/j.steroids.2004.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New polyhydroxylated sterols, stylisterol A-C (1-3), and a novel 5.19-cyclosterol, hatomasterol (4) were isolated from the Okinawan sponge Stylissa sp. Structural determinations of these compounds were made by spectroscopic analysis and chemical conversion. Assessment of cytotoxicity toward HeLa cells was also determined. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：63 / 70
页数：8
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