Epigenetics and Oxidative Stress in Aging

被引：143

作者：

Guillaumet-Adkins, Amy ^{[1
]}

Yanez, Yania ^{[2
]}

Peris-Diaz, Manuel D. ^{[3
]}

Calabria, Ines ^{[4
]}

Palanca-Ballester, Cora ^{[3
]}

Sandoval, Juan ^{[3
,5
]}

机构：

[1] Barcelona Inst Sci & Technol, CNAG CRG, Ctr Genom Regulat CRG, Barcelona, Spain

[2] Hosp Univ & Politecn La Fe, Pediat Oncol Unit, Valencia 46026, Spain

[3] Hlth Res Inst La Fe, Biomarkers & Precis Med Unit, Valencia 46026, Spain

[4] Hlth Res Inst La Fe, Genom Unit, Avda Fernando Abril Martorell, Valencia 46026, Spain

[5] Hlth Res Inst La Fe, Epigen Core Facil, Avda Fernando Abril Martorell, Valencia 46026, Spain

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2017年 / 2017卷

关键词：

DNA METHYLATION AGE; REGULATE LIFE-SPAN; ANTIOXIDANT DEFENSES; REACTIVE OXYGEN; ROS GENERATION; MITOCHONDRIAL; DAMAGE; REPAIR; MECHANISMS; BLOOD;

D O I：

10.1155/2017/9175806

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a multifactorial process characterized by the progressive loss of physiological functions, leading to an increased vulnerability to age-associated diseases and finally to death. Several theories have been proposed to explain the nature of aging. One of the most known identifies the free radicals produced by the mitochondrial metabolism as the cause of cellular and DNA damage. However, there are also several evidences supporting that epigenetic modifications, such as DNA methylation, noncoding RNAs, and histone modifications, play a critical role in the molecular mechanism of aging. In this review, we explore the significance of these findings and argue how the interlinked effects of oxidative stress and epigenetics can explain the cause of age-related declines.

引用

页数：8

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