Synthesis, Structural Characterization, Insecticidal and Fungicidal Activity of (1H-1,2,4-Triazol-5-yl) carbamatest

A series of novel (1H-1,2,4-triazol-5-yl)carbamates (5 and 6) was synthesized via the method of combining the crucial sub-structures of carbamates and 1H-1,2,4-triazole-5-amines in one molecules. Their structures were characterized by nuclear magnetic resonance (NMR), infrared (IR) spectrometry, high resolution mass spectrometry (HRMS) and elemental analysis. The preliminary insecticidal activity assays indicated that the lethal rates of target compounds to Myzus persicae were good at the concentration of 500 mu g/mL. And the lethal rate of several compounds was more than 90%. Further research of these compounds against Myzus persicae indicated that compound 5b showed considerably high activity with a LC50 of 9.49 mu g/mL, which confirmed that these compounds are valuable for further study. The preliminary fungicidal activity assays indicated that these compounds exhibited low fungicidal activity against tested fugi in vitro. At a dose of 50 mu g/mL, only a few of compounds gave limited inhibition on mycelium growth. In addition, the structure activity relationship was also discussed.