Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes

被引：53

作者：

Wu, Peng ^{[1
,2
]}

Deng, Gang ^{[1
]}

Sai, Xiyalatu ^{[1
,2
]}

Guo, Huiming ^{[1
]}

Huang, Huanlei ^{[1
]}

Zhu, Ping ^{[1
,2
]}

机构：

[1] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Dept Cardiac Surg, Guangzhou, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Clin Med 2, Guangzhou, Guangdong, Peoples R China

来源：

BIOSCIENCE REPORTS | 2021年 / 41卷 / 04期

基金：

中国国家自然科学基金;

关键词：

ACUTE MYOCARDIAL-INFARCTION; ENGINEERED HUMAN MYOCARDIUM; FUNCTIONAL MATURATION; CARDIAC DIFFERENTIATION; EXTRACELLULAR-MATRIX; PROMOTES MATURATION; MAMMALIAN TARGET; LONG-TERM; HEART; MUSCLE;

D O I：

10.1042/BSR20200833

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induced pluripotent stem cells (iPSCs) have the ability to differentiate into cardiomyocytes (CMs). They are not only widely used in cardiac pharmacology screening, human heart disease modeling, and cell transplantation-based treatments, but also the most promising source of CMs for experimental and clinical applications. However, their use is largely restricted by the immature phenotype of structure and function, which is similar to embryonic or fetal CMs and has certain differences from adult CMs. In order to overcome this critical issue, many studies have explored and revealed new strategies to induce the maturity of iPSC-CMs. Therefore, this article aims to review recent induction methods of mature iPSC-CMs, related mechanisms, and limitations.

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页数：16

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