Interrelatedness between C-reactive protein and oxidized low-density lipoprotein

被引：22

作者：

Obradovic, Milan M. ^{[1
]}

Trpkovic, Andreja ^{[1
]}

Bajic, Vladan ^{[1
]}

Soskic, Sanja ^{[1
]}

Jovanovic, Aleksandra ^{[1
]}

Stanimirovic, Julijana ^{[1
]}

Panic, Milos

Isenovic, Esma R. ^{[1
,2
]}

机构：

[1] Univ Belgrade, Vinca Inst Nucl Sci, Res Lab Radiobiol & Mol Genet, Belgrade 11000, Serbia

[2] Clin Hosp Ctr Zemun, Dept Cardiol, Zemun, Serbia

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2015年 / 53卷 / 01期

关键词：

C-reactive protein (CRP); C-reactive protein and oxidized low-density lipoprotein (OxLDL) interrelatedness; oxidized low-density lipoprotein; CORONARY-HEART-DISEASE; MIDDLE-AGED MEN; AORTIC ENDOTHELIAL-CELLS; CLINICAL-SIGNIFICANCE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; STATIN THERAPY; LDL; RISK;

D O I：

10.1515/cclm-2014-0590

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.

引用

页码：29 / 34

页数：6

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