Use of tumor necrosis factor (TNF) inhibitors in patients with HIV/AIDS

被引：57

作者：

Gallitano, Stephanie M. ^{[1
]}

McDermott, Laura ^{[1
]}

Brar, Kanwaljit ^{[2
]}

Lowenstein, Eve ^{[1
]}

机构：

[1] SUNY Downstate, Dept Dermatol, 450 Clarkson Ave,Box 46, Brooklyn, NY 11203 USA

[2] Natl Jewish Hlth, Div Pediat Allergy & Immunol, Denver, CO USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2016年 / 74卷 / 05期

关键词：

AIDS; autoimmune disease; hidradenitis suppurativa; HIV; inflammatory bowel disease; opportunistic infections; psoriasis; rheumatoid arthritis; tumor necrosis factor-alpha; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-POSITIVE PATIENT; FACTOR-ALPHA; PSORIATIC-ARTHRITIS; INFECTED PATIENT; FACTOR THERAPY; ETANERCEPT; INFLIXIMAB; ACTIVATION; MARKERS;

D O I：

10.1016/j.jaad.2015.11.043

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Patients with HIV and AIDS are living longer because of advancements in antiretroviral therapy. These patients are often susceptible to debilitating inflammatory disorders that are refractory to standard treatment. We discuss the relationship of tumor necrosis factor-alpha and HIV and then review 27 published cases of patients with HIV being treated with tumor necrosis factor-alpha inhibitors. This review is limited because no randomized controlled trials have been performed with this patient population. Regardless, we propose that reliable seropositive patients, who are adherent to medication regimens and frequent monitoring and have failed other treatment modalities, should be considered for treatment with tumor necrosis factor-alpha inhibitors.

引用

页码：974 / 980

页数：7

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