Gene transfer strategies in tissue engineering

被引：95
作者：
Bleiziffer, Oliver
Eriksson, Elof
Yao, Feng
Horch, Raymund E.
Kneser, Ulrich
机构：
[1] Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, D-91054 Erlangen, Germany
[2] Harvard Univ, Sch Med, Div Plast Surg, Brigham & Womens Hosp, Boston, MA 02115 USA
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2007年 / 11卷 / 02期
关键词：
gene therapy; tissue engineering; scaffold; gene-activated matrix; regeneration growth factor;
D O I：
10.1111/j.1582-4934.2007.00027.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aiming for regeneration of severed or lost parts of the body, the combined application of gene therapy and tissue engineering has received much attention by regenerative medicine. Techniques of molecular biology can enhance the regenerative potential of a biomaterial by co-delivery of therapeutic genes, and several different strategies have been used to achieve that goal. Possibilities for application are many-fold and have been investigated to regenerate tissues such as skin, cartilage, bone, nerve, liver, pancreas and blood vessels. This review discusses advantages and problems encountered with the different gene delivery strategies as far as they relate to tissue engineering, analyses the positive aspects of polymeric gene delivery from matrices and discusses advances and future challenges of gene transfer strategies in selected tissues.
引用
收藏
页码：206 / 223
页数：18
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