Single ablative intravesical electromotive mitomycin C administration for small non-muscle-invasive bladder cancer: a prospective study

被引：7

作者：

Decaestecker, Karel ^{[1
]}

Lumen, Nicolaas ^{[1
]}

Van Camp, Christel ^{[1
]}

Oosterlinck, Willem ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Urol, Ghent, Belgium

来源：

ACTA CLINICA BELGICA | 2018年 / 73卷 / 05期

关键词：

Electromotive drug administration; mitomycin; intravesical chemotherapy; urothelial bladder cancer; chemoresection; non-muscle-invasive-bladder cancer; RANDOMIZED CONTROLLED-TRIAL; CHEMOTHERAPY;

D O I：

10.1080/17843286.2018.1440706

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To explore the effect of electromotive drug administration of mitomycin C (EMDA-MMC) using a single dose of intravesical mitomycin C (MMC) to avoid transurethral resection (TURBT) for small non-muscle-invasive bladder cancer.Material and methods All patients presenting small (<2cm), single or multiple papillary bladder tumors were proposed to undergo a single EMDA-MMC instillation with 60mg MMC before planning TURBT. The end point is complete disappearance of all papillary tumors at 2-4weeks after EMDA-MMC.Results Thirty-six instillations were given to 32 patients. In general the treatment was well supported, except for two patients who had severe bladder spasms, resulting in early evacuation of the MMC. Complete response occurred in 28% (10/36 instillations). In 4 EMDA-MMCs with multiple tumors some tumors disappeared while others remained. In 61% (22/36) the tumors remained unchanged.Conclusion A single EMDA-MMC in l papillary bladder tumors <2cm gives insufficient ablative effect.

引用

页码：324 / 327

页数：4

共 11 条

[1]

Bono AV, 1996, EUR UROL, V29, P385

[2] Neoadjuvant Short-term Intensive Intravesical Mitomycin C Regimen Compared with Weekly Schedule for Low-grade Recurrent Non-muscle-invasive Bladder Cancer: Preliminary Results of a Randomised Phase 2 Study [J].