Pathophysiology & genetics of obstructive sleep apnoea

被引：0

作者：

Campana, Lisa ^{[1
,2
]}

Eckert, Danny J. ^{[1
,2
]}

Patel, Sanjay R. ^{[4
,5
]}

Malhotra, Atul ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Div Sleep Med, Sleep Disorders Program, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Brigham & Womens Hosp, Div Pulm Crit Care Med, Boston, MA 02115 USA

[4] Univ Hosp Cleveland, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Cleveland, OH 44106 USA

来源：

INDIAN JOURNAL OF MEDICAL RESEARCH | 2010年 / 131卷 / 02期

基金：

英国医学研究理事会;

关键词：

Arousal; genioglossus; lung; obstructive sleep apnoea; upper airway; ventilatory control stability; POSITIVE AIRWAY PRESSURE; CARDIAC RESYNCHRONIZATION THERAPY; GENIOGLOSSUS MUSCLE ACTIVATION; SEROTONERGIC EXCITATORY DRIVE; APOLIPOPROTEIN-E EPSILON-4; CHEMICAL CONTROL STABILITY; EYE-MOVEMENT SLEEP; WHOLE-GENOME SCAN; NEGATIVE-PRESSURE; LUNG-VOLUME;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Obstructive sleep apnoea (OSA) is a highly prevalent condition with proven neurocognitive and cardiovascular consequences. OSA patients experience repetitive narrowing or collapse of the pharyngeal airway during sleep. Multiple factors likely underlie the pathophysiology of this condition with considerable inter-individual variation. Important risk factors for OSA include obesity, male gender, and ageing. However, the mechanisms underlying these major risk factors are not well understood. We briefly review the state-of-the-art knowledge regarding OSA pathogenesis in adults and highlight the potential role of genetics in influencing key OSA pathophysiological traits.

引用

页码：176 / 187

页数：12

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