NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus

被引：17

作者：

Wang, Jie ^{[1
]}

Xiao, Mengjie ^{[1
]}

Wang, Jie ^{[1
]}

Wang, Shudong ^{[2
,3
]}

Zhang, Jingjing ^{[4
]}

Guo, Yuanfang ^{[1
]}

Tang, Yufeng ^{[5
]}

Gu, Junlian ^{[1
]}

机构：

[1] Shandong Univ, Sch Nursing, Cheeloo Coll Med, Jinan, Peoples R China

[2] Jilin Univ, Hosp 1, Dept Cardiol, Changchun, Peoples R China

[3] China Med Univ, Hosp 1, Dept Cardiol, Shenyang, Peoples R China

[4] Peoples Hosp Liaoning Prov, Dept Cardiol, Shenyang, Peoples R China

[5] Shandong First Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Jinan, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

NRF2; epigenetic modifications; activators; diabetic cardiac complication; diabetic vascular complication; APOPTOTIC CELL-DEATH; OXIDATIVE STRESS; NRF2; EXPRESSION; HIGH GLUCOSE; TRANSFORMATION; NEPHROPATHY; SULFORAPHANE; MICE; REACTIVATION; RETINOPATHY;

D O I：

10.3389/fendo.2021.598005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus (DM) is a highly prevalent chronic disease that is accompanied with serious complications, especially cardiac and vascular complications. Thus, there is an urgent need to identify new strategies to treat diabetic cardiac and vascular complications. Nuclear factor erythroid 2-related factor 2 (NRF2) has been verified as a crucial target for the prevention and treatment of diabetic complications. The function of NRF2 in the treatment of diabetic complications has been widely reported, but the role of NRF2-related epigenetic modifications remains unclear. The purpose of this review is to summarize the recent advances in targeting NRF2-related epigenetic modifications in the treatment of cardiac and vascular complications associated with DM. We also discuss agonists that could potentially regulate NRF2-associated epigenetic mechanisms. This review provides a better understanding of strategies to target NRF2 to protect against DM-related cardiac and vascular complications.

引用

页数：10

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