Boron Imidazolate Framework-Derived Porous Carbon Nanospheres for Dual-Mode Bioimaging-Guided Photothermal/Sonodynamic Synergistic Cancer Therapy

被引：10

作者：

Du, Linyao ^{[1
]}

Ren, Shuangsong ^{[1
]}

Qi, Ye ^{[2
]}

Wen, Ru ^{[1
]}

Feng, Yue ^{[1
]}

Tong, Mengying ^{[1
]}

Liu, Xiaohui ^{[3
]}

Li, Yachen ^{[3
]}

Che, Ying ^{[1
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Dept Ultrasound, 193 Lianhe Rd, Dalian 116011, Liaoning, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, Sch Chem Engn, 2 Linggong Rd, Dalian 116024, Liaoning, Peoples R China

[3] Dalian Med Univ, Dept Environm Hlth & Toxicol, Sch Publ Hlth, 9 West Sect Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China

来源：

ADVANCED THERAPEUTICS | 2022年 / 5卷 / 06期

关键词：

boron imidazolate framework; multi-mode bioimaging; photothermal therapy; porous carbon nanospheres; sonodynamic therapy; SONODYNAMIC THERAPY; RECENT PROGRESS; NANOPARTICLES;

D O I：

10.1002/adtp.202200033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Development of efficient nanotherapeutic agents to enhance anticancer therapeutic effects is challenging. In this study, photo/sono-dual-responsive boron imidazolate framework-derived single-component porous carbon nanospheres (PCNSs) are successfully developed for dual-mode bioimaging-guided photothermal/sonodynamic (PTT/SDT) synergistic therapy for triple-negative breast cancer. The PCNS not only exhibits satisfactory and excellent photothermal conversion ability under near-infrared laser irradiation but also demonstrates a promising capability as an efficient sonosensitizer to generate cytotoxic reactive oxygen species through inertial cavitation in response to low-intensity ultrasound stimulation. The outstanding photothermal effect enhances the blood flow in tumor tissues and thus improves the oxygen supply, helping to achieve a remarkable synergistic therapeutic effect in the PTT/SDT synergistic therapy without any tumor recurrence or systemic toxicity. Interestingly, the PCNS enables the precise visualization of solid tumors using contrast-enhanced ultrasound and photothermal dual-modal bioimaging techniques. Overall, this study provides valuable insights in developing all-in-one theranostic nanoplatforms for the clinical treatment of triple-negative breast cancer.

引用

页数：9

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