Vti Proteins: Beyond Endolysosomal Trafficking

被引：23

作者：

Emperador-Melero, Javier ^{[1
,2
]}

Toonen, Ruud F. ^{[1
,2
]}

Verhage, Matthijs ^{[1
,2
,3
]}

机构：

[1] Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Funct Genom, Fac Exact Sci,VUmc,Neurosci Campus Amsterdam, De Boelelaan 1087, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, De Boelelaan 1087, NL-1081 HV Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Neurosci Campus Amsterdam, Clin Genet,VUmc, De Boelelaan 1087, NL-1081 HV Amsterdam, Netherlands

来源：

NEUROSCIENCE | 2019年 / 420卷

关键词：

vesicle biogenesis; exocytosis; dense core vesicle; secretory vesicle; SNARE proteins; TRANS-GOLGI NETWORK; COG COMPLEX INTERACTS; V-SNARE VTI1P; VESICLE TRANSPORT; RETROGRADE TRANSPORT; HOMOTYPIC FUSION; MEMBRANE-FUSION; T-SNARES; ENDOSOMES; DOMAINS;

D O I：

10.1016/j.neuroscience.2018.11.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vti proteins are conserved from yeast to humans and regulate intracellular membrane trafficking by providing one specific SNARE domain, the Qb SNARE, to the four helical SNARE bundle that drives membrane fusion. Two mammalian Vti genes, Vti1a and Vti1b are reported to regulate distinct aspects of endolysosomal trafficking and retrograde transport to the Golgi, but have also been implicated in synaptic vesicle secretion. In this review, we summarize the current evidence for the role of Vti proteins in intracellular trafficking in different cells. We propose that, despite some unique aspects, the two mammalian VTI genes have largely redundant functions in neurosecretory cells and recycle molecules required for the sorting of regulated cargo to the Golgi. Defects in this recycling also lead to defects in synaptic transmission and dense core vesicle secretion. This article is part of a Special Issue entitled: SNARE proteins: a long journey of science in brain physiology and pathology: from molecular. (C) 2018 The Author(s). Published by Elsevier Ltd on behalf of IBRO.

引用

页码：32 / 40

页数：9

共 88 条

[1] Structural Basis for the Interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6 [J].